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Last Updated: 2 years ago

Possible Interaction: Caffeine and Midazolam

supplement:

Caffeine

Research Papers that Mention the Interaction

Results: CAF caused a statistically significant increase in AC3 positive cells when coadministered with midazolam (p = 0.002), ketamine (p = 0.014), or fentanyl (p < 0.001).
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians  •  2017  |  View Paper
Such alterations in hepatic P450 significantly resulted in an increase in the plasma concentrations of substrate drugs caffeine [1A2], tolbutamide [2C11], chlorzoxazone [2E1], and midazolam [3A2]) for each P450 isoform, and thus, the hypnotic action of midazolam could be significantly prolonged.
Drug Metabolism and Disposition  •  2013  |  View Paper
The synergistic production of fine motor dyskinesia by the concurrent administration of caffeine and midazolam may be relevant to the triggering of anxiety attacks by caffeine observed in panic disorder patients.
Pharmacology Biochemistry and Behavior  •  1991  |  View Paper
The conspicuous synergistic action of caffeine on the motor control deficit produced by midazolam contrasts with the typical antagonism found between the benzodiazepines and methylxanthines when performance is evaluated by psychomotor tests not requiring fine motor control.
When each dose of caffeine was combined with 3 mg/kg midazolam , a marked synergism in motor performance impairment occurred.
Pharmacology Biochemistry and Behavior  •  1991  |  View Paper
Mixtures of low doses of caffeine and midazolam frequently antagonized GABA responses.
Neuroscience Letters  •  1984  |  View Paper
It was however possible to detect a narrow range of concentrations of midazolam which had an additive effect to the enhancement by caffeine.
Neuropharmacology  •  1983  |  View Paper
The hypodipsic effect of caffeine was reversed by benzodiazepine treatment ( midazolam or diazepam).
Pharmacology Biochemistry and Behavior  •  1982  |  View Paper