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Last Updated: a month ago

Possible Interaction: Caffeine and Mianserin

supplement:

Caffeine

Research Papers that Mention the Interaction

Adora1, Slc6a15, and Comt may be involved in the antidepressant-like effect observed after joint administration of caffeine and mianserin or agomelatine, following chronic treatment with caffeine.
In mice treated with caffeine for 14 days, joint administration of agomelatine or mianserin and caffeine on day 15 decreased solute carrier family 6, member 15 (Slc6a15), messenger RNA (mRNA) level in the Cx, compared to the group which received only the respective antidepressant on this day.
Moreover, in mice treated with caffeine for 14 days, joint administration of mianserin and caffeine on day 15 decreased adenosine A1 receptor (Adora1) and catechol-O-methyltransferase (Comt) mRNA level in the Cx, compared to the group which received mianserin without caffeine on this day.
Psychopharmacology  •  2018  |  View Paper
RESULTS Caffeine increases the anti-immobility action of mianserin and agomelatine.
RESULTS Caffeine increases the anti-immobility action of mianserin and agomelatine.
Pharmacological reports : PR  •  2016  |  View Paper