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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Caffeine
drug:
Mexiletine
Research Papers that Mention the Interaction
“Conversely, mexiletine is known to alter the disposition of other drugs, such as caffeine and theophylline.”
Clinical Pharmacokinetics of Mexiletine“Smoking enhances caffeine clearance in both healthy volunteers and patients with severe hepatic disorders, whereas co-medication with mexiletine strongly inhibits caffeine elimination.”
“In an acute experiment in healthy volunteers and in patients under long-term treatment for cardiac arrhythmias, mexiletine inhibits caffeine elimination by about 50%.”
“Some side effects of mexiletine may possibly at least partially be attributable to a retention of caffeine.”
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