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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Caffeine
drug:
Methylphenidate
Research Papers that Mention the Interaction
“The behaviour of one child deteriorated while he was taking methylphenidate and caffeine.”
Individual responses to methylphenidate and caffeine in children with minimal brain dysfunction.“Twice daily injections of caffeine induced significant cross tolerance (i.e., increased ED(50)) to the amphetamine-like discriminative effects of methylphenidate and SKF 81297, attenuated non-significantly the effects of NPA, and did not alter the effects of amphetamine.”
Caffeine induces differential cross tolerance to the amphetamine-like discriminative stimulus effects of dopaminergic agonists“Conversely, injections of methylphenidate (3.0 mg/kg) increased the ED50 of caffeine from 5.2 to 15 mg/kg.”
“Twice daily injection of caffeine (30 mg/kg) for 3-1/2 days increased the ED50 of methylphenidate for caffeine-appropriate responding from 1.5 to 5.5 mg/kg.”
“ Caffeine ingestion significantly improved mood state scores for vigor by 17% (P = 0.009) and reduced absolute error by 35% (P = 0.045) during coincidence anticipation assessment at 8 mph compared to placebo.”
Assessment of the ergogenic effect of caffeine supplementation on mood, anticipation timing, and muscular strength in older adults
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