Possible Interaction: Caffeine and Methamphetamine

“Co-treatment of non-toxic concentrations of METH , at 0.5 mM, and caffeine , at 1 mM, caused reduction of the cell viability.”

“In conclusion, we proposed the augmented hazard associated with caffeine and METH combination in Ya-Ba abusers.”

“Our results suggested that caffeine potentiates METH toxicity through inhibition of autophagy and that autophagy serves as a protective mechanism.”

“Previous study demonstrated that caffeine potentiates the toxic effect of METH in association with the production of reactive oxygen species and the induction of apoptosis.”

“Since METH causes induction of autophagy, the question was raised whether this pathway participates in the potentiating effect of caffeine on METH neurotoxicity.”

“ MA may only be anxiolytic for females when accompanied by 31mg/kg/day caffeine.”

“In vivo data showed that combined administration of METH and CAF increased the mortality rate of rats, with an increase in the level of thiobarbituric acid reactive substances (TBARS), the indicator of oxidative stress, in striatal tissues.”

“The results indicate that caffeine potentiates the toxic effects of methamphetamine , possibly via a mechanism involving an increase in dopamine release and excess ROS generation.”

“We found that combined treatment of METH and CAF at individually non-toxic concentrations significantly decreased viability of human neuroblastoma SK-N-SH cells.”

“We have recently reported that nonselective adenosine receptor antagonists caffeine and 3,7-dimethyl-1-propargylxanthine) can partially substitute for the discriminative-stimulus effects of methamphetamine.”

“Furthermore, cocoa (0.1, 0.3 and 1 g/kg), theobromine (3, 10, 30 and 100 mg/kg) and caffeine (3, 10, 30 and 100 mg/kg) enhanced the ambulation-increasing effect of methamphetamine (2 mg/kg s.c.).”

“In contrast, the repeated administration of methamphetamine 2 mg/kg induced not only reverse tolerance to methamphetamine itself but also cross reverse tolerance to caffeine (30 mg/kg).”

“The combined administration of caffeine (1-100 mg/kg) and methamphetamine (2 mg/kg) showed a synergistic action as compared with the effects of the individual drugs.”