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Last Updated: 2 years ago

Possible Interaction: Caffeine and Methacholine

supplement:

Caffeine

Research Papers that Mention the Interaction

In the guinea-pig trachealis, 25 mM but not 2.5 mM caffeine totally blocked any contractile effect of methacholine or histamine, but not of KCl, whose contractile effect relies on extracellular Ca++.
Archives internationales de pharmacodynamie et de therapie  •  1991  |  View Paper
In addition, caffeine pretreatment inhibited methacholine (a selective muscarinic agonist)- and thapsigargin (thapsigargin depletes inositol 1,4,5-trisphosphate-sensitive Ca++ pools)-induced increases in [Ca++]in as well as methacholine-induced secretion.
The Journal of pharmacology and experimental therapeutics  •  1993  |  View Paper
Caffeine induced approximately 30% of the response to methacholine , and phenylephrine, a tension less than 30% of that with methacholine.
Journal of applied physiology  •  1986  |  View Paper