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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Caffeine
drug:
Methacholine
Research Papers that Mention the Interaction
“In the guinea-pig trachealis, 25 mM but not 2.5 mM caffeine totally blocked any contractile effect of methacholine or histamine, but not of KCl, whose contractile effect relies on extracellular Ca++.”
Effect of caffeine on tone and intracellular Ca++ release in guinea-pig and human trachealis.“In addition, caffeine pretreatment inhibited methacholine (a selective muscarinic agonist)- and thapsigargin (thapsigargin depletes inositol 1,4,5-trisphosphate-sensitive Ca++ pools)-induced increases in [Ca++]in as well as methacholine-induced secretion.”
Effects of caffeine on cholinergic agonist- and K(+)-induced cytosolic Ca++ signals and secretion in porcine adrenal chromaffin cells.“ Caffeine induced approximately 30% of the response to methacholine , and phenylephrine, a tension less than 30% of that with methacholine.”
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