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Last Updated: 2 years ago

Possible Interaction: Caffeine and Menthol

supplement:

Caffeine

drug:

Menthol

Research Papers that Mention the Interaction

ConclusionsWe conclude that a single oral dose of pure menthol (100 mg) delays caffeine absorption and blunts the heart-rate slowing effect of caffeine, but does not affect caffeine metabolism.
ResultsCo-administration of menthol resulted in an increase of caffeine tmax values from 43.6±20.6 min (mean±SD) to 76.4±28.0 min (P<0.05).
The Cmax values of caffeine were lower in the menthol phase than in the placebo phase, but this effect was not statistically significant (P=0.06).
European Journal of Clinical Pharmacology  •  2003  |  View Paper
Menthol and MS produced muscle contraction per se at high concentration and enhanced the caffeine elicited contractile activity.
Nihon yakurigaku zasshi. Folia pharmacologica Japonica  •  1984  |  View Paper