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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Caffeine
supplement:
Mechlorethamine
Research Papers that Mention the Interaction
“ Caffeine enhances lethality of agents such as HN2.”
Interference with DNA repair mechanisms of mammalian cells: cell cycle dependence.“The addition of 2 mM caffeine during the first 24 hr after nitrogen mustard decreased viability more than 95%.”
Abolition by cycloheximide of caffeine-enhanced lethality of alkylating agents in hamster cells.“ Caffeine (2mM) increased the lethality of HN2 by 5- to 10-fold.”
“Our results show that caffeine potentiates the lethality of the nitrogen mustard 2-chloro-N-(2-chloroethyl)-N-methylethanamine (HN2) by inducing damaged cells to undergo mitosis before properly repairing lesions in their DNA.”
“Evidently this effect is due to inhibition of the action of caffeine by nitrogen mustard since nitrogen mustard also causes a decreasein the efficiency of caffeine after UV-irradiation.”
The action of caffeine on the survival of proteus mirabilis and its virulent phage VIr after UV-irradiation and treatment with nitrogen mustard.“When sensitized to mustard action by treatment with iodoacetamide, acriflavine or caffeine , the extent of alkylation of cellular DNA corresponding to a mean lethal dose was decreased to approximately 3 molecules of di(guanin-7-ylethyl) sulphide in the genome of this strain.”
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