Possible Interaction: Caffeine and Magnesium

“There is evidence that magnesium deficit is involved in addiction to various addictive substances (heroin, morphine, cocaine, nicotine, alcohol, caffeine , and others).”

“The consecutive groups of patients were administered antibiotic and fluids in dose as mentioned above, and additionally oral caffeine 3 x 200 mg (n = 40); caffeine plus magnesium 2 x 1 g daily i.v. (”

“The percent reabsorption of calcium (98.6% to 97.5%, p less than .001) and magnesium (97.0% to 94.2%, p less than .0001) decreased significantly during the post-caffeine period.”

“Total urine output of water, calcium, magnesium , sodium, chloride, potassium and creatinine increased in the two hours following caffeine ingestion when compared to the control beverage.”

“… caffeine … magnesium (half-inhibition 1.4-4.2 mM compared with 0.97 mM for caffeine) and ruthenium red (half-inhibition for trifluoperazine, W7 and compound … this drug-induced calcium release occurs via the calcium-gated calcium channel of sarcoplasmic reticulum stimulated by caffeine or channels with similar properties.”

“It is proposed that chlorpromazine, caffeine or d -amphetamine can evoke catecholamine release by mobilizing different calcium pools within the adrenal medullary chromaffin cell and that magnesium can block this effect.”

“The major findings show that caffeine increases urinary excretion of calcium, sodium and magnesium , in addition to a diuretic action with consumption > 300–360 mg (approximately four cups of coffee).”

“Abstract The study of the cytokinesis inhibition by caffeine in meristem cells of onion root tips has shown the antagonism between calcium and/or magnesium and caffeine.”