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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Caffeine
drug:
Levetiracetam
Research Papers that Mention the Interaction
“ Caffeine (1–7.5 mg/kg) … reduced the antinociceptive effects of levetiracetam (25 mg/kg) (first phase P = 0.002, second phase P < 0.001) and sumatriptan (2.5 mg/kg) (… phase P = 0.014, second phase P = 0.027); dose-dependent inhibition was observed in the second phase.”
The Effects of Levetiracetam, Sumatriptan, and Caffeine in a Rat Model of Trigeminal Pain: Interactions in 2-Component Combinations“ Levetiracetam's ED50 in the presence of caffeine was reduced approximately 11-fold.”
“Naloxone (75–300 nmol/paw), CTAP (1–5 nmol/paw); yohimbine (…–200 nmol/paw), MK-912 (5–20 nmol/paw); caffeine (500–1500 nmol/paw), DPCPX (3–30 nmol/paw); methysergide (10–100 nmol/paw) …/paw); but not bicuculline (400 nmol/paw), significantly depressed the antihyperalgesic effects of levetiracetam (…).”
“Treatment with LEV (33 microM) prior to stimulation of RyR-mediated CICR by caffeine led to a 61% decrease in the caffeine induced peak height of [Ca2+]i when compared to the control.”
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