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“PURPOSE To determine whether biochemical modulation with LV leucovorin ) enhances the efficacy of CAF (cyclophosphamide, doxorubicin, and fluorouracil) against metastatic breast cancer. ”
Journal of clinical oncology : official journal of the American Society of Clinical Oncology • 2003 | View Paper
“ Folin administered showed a significant antagonistic effect to caffeine induced hyperactivity and slightly prolonged hexobarbital induced sleeping time in mice.”