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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“In vitro, caffeine significantly decreased the mRNA expression of leptin , CREB and ADORA2A in concentration and time-dependent manners.”
“PCE induced a lower level of fetal blood leptin, which the primary mechanism is that caffeine inhibited antagonized Adora2a and AC activities to decreased cAMP synthesis, thus inhibited the expression of the transcription factor CREB and target gene leptin in the placenta.”
Prenatal caffeine exposure induced a lower level of fetal blood leptin mainly via placental mechanism.“Results Leptin was overexpressed in nearly all five primary CAF lines compared with its expression in paired NLFs.”
“Therefore, these results suggest caffeine may have pharmacological properties that ameliorate leptin resistance by reducing ER stress.”
“The CAF diet enhanced leptin serum levels and the long form of leptin receptor (Ob-Rb) mRNA expression in the uterus.”
Induction of uterine hyperplasia after cafeteria diet exposure“ CAF feeding increased the weight gain, relative retroperitoneal white adipose tissue (RWAT %), and plasma levels of glucose, insulin, triglycerides and leptin and decreased the insulin sensitivity.”
“ Caffeine decreased the expression of adipogenesis-related genes including peroxisome proliferator-activated receptor-γ, CCAAT/enhancer-binding protein-α, adipocyte lipid binding protein, lipoprotein lipase, leptin , and TNFα in a dose-dependent manner.”
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