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Last Updated: 2 years ago

Possible Interaction: Caffeine and Leptin

supplement:

Caffeine

drug:

Leptin

Research Papers that Mention the Interaction

In vitro, caffeine significantly decreased the mRNA expression of leptin , CREB and ADORA2A in concentration and time-dependent manners.
PCE induced a lower level of fetal blood leptin, which the primary mechanism is that caffeine inhibited antagonized Adora2a and AC activities to decreased cAMP synthesis, thus inhibited the expression of the transcription factor CREB and target gene leptin in the placenta.
Toxicology and applied pharmacology  •  2015  |  View Paper
Results Leptin was overexpressed in nearly all five primary CAF lines compared with its expression in paired NLFs.
BioMed research international  •  2019  |  View Paper
Therefore, these results suggest caffeine may have pharmacological properties that ameliorate leptin resistance by reducing ER stress.
Neuroscience Letters  •  2014  |  View Paper
The CAF diet enhanced leptin serum levels and the long form of leptin receptor (Ob-Rb) mRNA expression in the uterus.
Molecular and Cellular Endocrinology  •  2018  |  View Paper
CAF feeding increased the weight gain, relative retroperitoneal white adipose tissue (RWAT %), and plasma levels of glucose, insulin, triglycerides and leptin and decreased the insulin sensitivity.
PloS one  •  2016  |  View Paper
Caffeine decreased the expression of adipogenesis-related genes including peroxisome proliferator-activated receptor-γ, CCAAT/enhancer-binding protein-α, adipocyte lipid binding protein, lipoprotein lipase, leptin , and TNFα in a dose-dependent manner.
Toxicology in vitro : an international journal published in association with BIBRA  •  2013  |  View Paper