“Combinations of 17.8 mg/kg CAF with either 1.0, 1.8, 3.2, 5.6, or 10.0 mg/kg KET yielded the highest antinociceptive potentiations.”
“The median effective dose (ED(50)) of KET alone was 7.2 +/- 1.4 mg/kg, whereas … ED(50) of KET + CAF 17.8 mg/kg was 0.4 +/- 0.6 mg/kg: KET in the … of CAF was approximately 18 times more potent … the analgesic drug without CAF.”