Possible Interaction: Caffeine and Ketoconazole

“The pharmacokinetics of each compound administered as … were significantly altered after the administration of ketoconazole and fluvoxamine, showing statistically significant (p < 0.01) 12.8-, 8.1- and 3.2-fold … the area under the plasma concentration-time curve from time zero to infinity (AUC∞) for midazolam, caffeine and ….”

“We recently demonstrated that ketoconazole inhibits caffeine and aminopyrine oxidation in the rat; we now study the influence of ketoconazole on theophylline and chlordiazepoxide kinetics in man.”