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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“Results: CAF caused a statistically significant increase in AC3 positive cells when coadministered with midazolam (p = 0.002), ketamine (p = 0.014), or fentanyl (p < 0.001).”
Caffeine combined with sedative/anesthetic drugs triggers widespread neuroapoptosis in a mouse model of prematurity“ Caffeine enhanced the locomotor hyperactivity, caused disruption of the rotarod performance, and mortality rates due to ketamine , whereas prepulse inhibition deficits and anaesthesia remained unaffected.”
“These findings demonstrate that use of ketamine in combination with caffeine enhances its stimulant responses and lethal risk, suggesting that a potentially toxic interaction exists between ketamine and caffeine.”
Behavioural and toxic interaction profile of ketamine in combination with caffeine.“Motor activity produced by subthreshold dose (2.5 mg/kg) of ketamine was significantly increased by DMPX (selective A1 receptor antagonist) and caffeine (A1/A2 adenosine receptor antagonist), but not by DPCPX (selective A1 adenosine receptor antagonist).”
“6 The positive inotropic effect of ketamine was inhibited by verapamil (10−6 m) and by caffeine (4 × 10−3 m).”
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