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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
supplement:
Caffeine
drug:
Isavuconazole
Research Papers that Mention the Interaction
“Compared … isavuconazole changed the area under the concentration‐time curves (AUC∞) and maximum concentrations (… 42%, Cmax reduced 31%; repaglinide, AUC∞ reduced 8%, Cmax reduced 14%; caffeine , AUC∞ increased 4%, Cmax reduced 1%; dextromethorphan, AUC∞ increased 18%, Cmax increased …%, Cmax increased 3%; S‐methadone, AUC∞ reduced 35%, Cmax increased 1%.”
Pharmacokinetic Effects of Isavuconazole Coadministration With the Cytochrome P450 Enzyme Substrates Bupropion, Repaglinide, Caffeine, Dextromethorphan, and Methadone in Healthy Subjects
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