supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 5 years ago
supplement:
Caffeine
drug:
Indomethacin
Research Papers that Mention the Interaction
“The administration of indomethacin reconstituted both thein vitro lymphocyte responses and delayed cutaneous hypersensitivity.”
Modulation of immunologic responses in nontuberculous mycobacterial infections with indomethacin“ Indomethacin induced penetrating ulcerations of theintestine that were maximal at hour 24.Copperindomethacinate induced significantly lessulceration than indomethacin with no significantdifference in MPO and iNOS activities.”
Copper-Indomethacinate Associated with Zwitterionic Phospholipids Prevents Enteropathy in Rats (Effect on Inducible NO Synthase)“The results show that the combination of caffeine with indomethacin , an inhibitor of prostaglandin synthesis, mediated caffeine's effect by increasing cellular viability and lowering superoxide anion production and DNA fragmentation.”
“i) Indomethacin inhibits Ca2+ release induced by IP3 or caffeine. (”
“v) Indomethacin itself inactivates this G‐protein by stimulation of a GTPase activity and reverses the activation of G‐protein induced by IP3 or caffeine. (”
“The present preliminary findings suggest that caffeine when given together with indomethacin reduces the indomethacin-induced inhibition of PGI2 release from the gastric mucosa.”
“Pretreatment with indomethacin inhibited the effect of caffeine.”
“Summary Caffeine has been found to potentiate the acute anti-inflammatory activity of aspirin, indomethacin , and phenylbuta-zone, but not the activity of sodium salicy-late or hydrocortisone, in the carrageenan pleurisy or hindlimb models of inflammation in the rat.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback