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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Caffeine
drug:
Imipramine
Research Papers that Mention the Interaction
“A decrease in the antidepressant drug concentrations in brain was observed in the case of imipramine administered together with caffeine.”
Caffeine enhances the antidepressant-like activity of common antidepressant drugs in the forced swim test in mice“ Imipramine decreased the rate of 3-N-, 1-N- and 7-N-demethylations, and 8-hydroxylation of caffeine , the effect on 3-N-demethylation being most pronounced (Ki = 33 microM).”
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