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Discover Supplement-Drug Interactions

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Last Updated: 3 months ago

Possible Interaction: Caffeine and Idarubicin



Research Papers that Mention the Interaction

Based on in vitro data suggesting an enhancement by methylxanthines of IDA influx in leukemia cells, this study was designed to test the hypothesis that a commonly used methylxanthine, caffeine, might influence the myocardial uptake of IDA.
Caffeine reversed the cardiodepressive action of IDA (49% decrease in left ventricular developed pressure at the end of infusion) to a positive inotropic effect (18% increase of basal level).
We speculate that co-administration of caffeine may enhance the chronic cardiotoxicity of IDA by increasing its accumulation in the heart.
Naunyn-Schmiedeberg's Archives of Pharmacology  •  2003  |  View Paper