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Discover Supplement-Drug Interactions
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Last Updated: 3 months ago
supplement:
Caffeine
drug:
Idarubicin
Research Papers that Mention the Interaction
“Based on in vitro data suggesting an enhancement by methylxanthines of IDA influx in leukemia cells, this study was designed to test the hypothesis that a commonly used methylxanthine, caffeine, might influence the myocardial uptake of IDA.”
“ Caffeine reversed the cardiodepressive action of IDA (49% decrease in left ventricular developed pressure at the end of infusion) to a positive inotropic effect (18% increase of basal level).”
“We speculate that co-administration of caffeine may enhance the chronic cardiotoxicity of IDA by increasing its accumulation in the heart.”
Caffeine enhances myocardial uptake of idarubicin but reverses its negative inotropic effect
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