Possible Interaction: Caffeine and Hydrocortisone

“However, these data suggest that caffeine lowers the threshold for exercise-induced beta-endorphin and cortisol release , which may contribute to the reported benefits of caffeine on exercise endurance.”

“…,caffeine ingestion was associated with a greater increase in plasma lactate (caffeine: +1.0 +/- 0.2 mmol/L; placebo, +0.…; P < 0.005), epinephrine (caffeine, +223 +/- 82 pg/mL; placebo, +56 +/- 26 pg/mL; P < 0.05), and cortisol (caffeine, +12 +/- 3 mg/mL; …/mL; P < 0.001) levels.”

“The ratio of HC to total integrated value (which is also used as a selective indicator of vagal activity) was also significantly higher (P < 0.04) after caffeine consumption.”

“Compared to placebo, caffeine also produced significant increases of diastolic blood pressure and cortisol.”

“1 Our unit recently reported that the single-dose oral administration of caffeine produces dose-related and statistically significant increases in the plasma cortisol level.”

“In fasting male volunteers caffeine caused an increase in the concentrations of blood glucose, cortisol , insulin, free fatty acids, free glycerol and ketone bodies.”

“There is some evidence that caffeine ingestion, compared with a placebo, may lead to greater increases in the production of testosterone and cortisol following resistance exercise.”

“ Cortisol concentrations also increased with CAF + CHO intake compared with PLA; however, there was no significant effect of CAF + CHO supplementation on testosterone concentrations.”

“SP-B mRNA was synergistically induced also by administration of caffeine with hydrocortisone (87.9±39.0), prednisolone (154±66.8), and betamethasone (123±6.4).”

“A significant interaction effect (treatment and time) was found for cortisol and glucose concentrations; both increased with caffeine and decreased with placebo.”

“Exercise alone did not increase cortisol, but caffeine taken before exercise elevated cortisol in both men and women (ps<.05).”