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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Caffeine
drug:
Hydralazine
Research Papers that Mention the Interaction
“ Hydralazine inhibited the contraction of permeabilized vessels and the increase in smooth muscle cell Ca2+ concentration evoked by caffeine with similar concentration dependence, but with lower potency than its effect on IP3 contractions.”
Mechanisms of hydralazine induced vasodilation in rabbit aorta and pulmonary artery“In a Ca2+-free medium, the contractions provoked by noradrenaline or caffeine were significantly inhibited by the new hydrazinopyridazines and by hydralazine.”
“However, hydralazine suppressed the caffeine- and IP3-induced contractions in the skinned fibers relatively less than both the transient response to caffeine and phasic response to histamine in intact muscles, respectively.”
“ caffeine significantly (p = … mg/kg hydralazine (for 1 mg/kg hydralazine delta of 6.4 +/- 46.7 and 142.4 +/- 142.9 renin activity/min/kg body weight ….8 +/- 73.9 and 600.8 +/- 168.9 renin activity/min/kg body weight in control and caffeine-treated animals, respectively).”
“ Caffeine‐induced contractions were less sensitive to block by hydralazine.”
“ Hydralazine inhibited the contraction induced by caffeine in a Ca2+-free (EGTA) high potassium medium in a concentration-dependent manner (IC50: 8.43 X 10(-3) M).”
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