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Possible Interaction: Caffeine and Histamine

supplement:

Caffeine

Research Papers that Mention the Interaction

RESULTS While caffeine had no effect on …, mean (95% confidence interval) log PC20 histamine was significantly higher 150 minutes [caffeine = 0.99 (0.2) mg/ml, placebo = 0.53 (0.…)] and 240 minutes [caffeine = 0.89 (0.24), placebo = 0.44 (0.26)] after administration of caffeine than … placebo.
RESULTS While caffeine had no effect … FEV1, mean (95% confidence interval) log PC20 histamine was significantly higher 150 minutes [caffeine = 0.99 (0.2) mg/ml, placebo = 0.53 (0.…)] and 240 minutes [caffeine = 0.89 (0.24), placebo = 0.44 (0.26)] after administration of caffeine than … placebo.
Thorax  •  1993  |  View Paper
However, these methylxanthines were unable, at concentrations ranging from 0.1 mM to 10 mM, either to mobilize Ca2+ from internal stores or to block the initial Ca2+ rise evoked by histamine.
In addition, both methylxanthines showed at high concentrations (10–20 mM) a moderate inhibitory action on the production of InsP3 induced by histamine.
caffeine … histamine stimulation leads systematically to an increased Ca2+ sequestration in InsP3-sensitive Ca2+ pools, the effect observed with theophylline being stronger than that resulting from … cAMP concentration since neither forskolin (10–50 μM) nor 8-Br-cAMP (1 mM) caused an inhibition of the InsP3-induced Ca2+ oscillations.
Pflügers Archiv  •  1994  |  View Paper
Drugs capable of increasing cellular levels of CAMP such as β-adrenergic agents and methylxanthines inhibit the antigen-induced release of both histamine and SRS-A from human lung and these agents demonstrate synergism when used together.
The Journal of experimental medicine  •  1971  |  View Paper
Recently, drugs of the catecholamine and methylxanthine series were shown to inhibit the release of histamine from human leukocytes: evidence was presented to suggest that they operated through the cyclic 3′5′ AMP system (5, 6).
Journal of immunology  •  1969  |  View Paper
Methylxanthines and catecholamines both inhibit antigenically induced histamine release from human leukocytes.
Science  •  1968  |  View Paper
Drugs capable of increasing cellular levels of CAMP such as beta-adrenergic agents and methylxanthines inhibit the antigen-induced release of both histamine and SRS-A from human lung and these agents demonstrate synergism when used together.
The Journal of experimental medicine  •  1971  |  View Paper
The process of heterologous histamine-induced desensitization of the Ca2+ response in CHOhumH1 cells can be … to an alteration at the level of the intracellular Ca2+ pool, as the Ca2+ response of caffeine (10 mM), which releases Ca2+ from intracellular …+ stores was also attenuated upon short-term histamine exposure.
British journal of pharmacology  •  1996  |  View Paper
In the guinea-pig trachealis, 25 mM but not 2.5 mM caffeine totally blocked any contractile effect of methacholine or histamine , but not of KCl, whose contractile effect relies on extracellular Ca++.
Archives internationales de pharmacodynamie et de therapie  •  1991  |  View Paper
Histamine level significantly increased beginning 30 min after caffeine administration and remained elevated for at least 140 min.
American journal of physiology. Regulatory, integrative and comparative physiology  •  2014  |  View Paper
Caffeine (0.1 mg/kg) inhibited to 56.4+/-… anaphylactic shock activated by anti-DNP IgE. Caffeine (5-… histamine release from rat peritoneal mast cells (RPMCs) activated by compound 48/80 or anti-DNP IgE. … mM) inhibited by 96.7+/-0.5% histamine release activated by compound 48/80.
Caffeine is known to reduce evoked histamine secretion, but the effects of caffeine on anaphylactic shock have not been clarified.
International journal of immunopharmacology  •  2000  |  View Paper
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