Possible Interaction: Caffeine and Histamine

“RESULTS--While caffeine had no effect on …, mean (95% confidence interval) log PC20 histamine was significantly higher 150 minutes [caffeine = 0.99 (0.2) mg/ml, placebo = 0.53 (0.…)] and 240 minutes [caffeine = 0.89 (0.24), placebo = 0.44 (0.26)] after administration of caffeine than … placebo.”

“4 The process of heterologous histamine‐induced desensitization of the Ca2+ response in CHOhumH1 cells can be … to an alteration at the level of the intracellular Ca2+ pool, as the Ca2+ response of caffeine (10 mM), which releases Ca2+ from intracellular …+ stores was also attenuated upon short‐term histamine ….”

“In the guinea-pig trachealis, 25 mM but not 2.5 mM caffeine totally blocked any contractile effect of methacholine or histamine , but not of KCl, whose contractile effect relies on extracellular Ca++.”

“Recently, drugs of the catecholamine and methylxanthine series were shown to inhibit the release of histamine from human leukocytes: evidence was presented to suggest that they operated through the cyclic 3′5′ AMP system (5, 6).”

“We hypothesized that caffeine increases glutamate release in the posterior hypothalamus (PH) and produces increased activity of wake-active histamine neurons.”

“Simultaneous application of histamine (100 μM) and caffeine (8 mm) during H1 receptor blockade activated ICl(Ca), but not ICat.”

“10 mM caffeine (CAF) increased of [Ca2+]i in NPE and PE (NPE > PE) and sometimes produced very slow oscillations with an interval of 10 to 25 s. Prior administration of CAF strongly suppressed the effects of ACH, CARB, EPI, PHE, histamine , and adenosine 5-triphosphate (ATP).”

“ Histamine‐induced currents were blocked by caffeine (10 mM) but could be recorded in Ca(2+)‐free bathing solutions.”

“Conversely, pretreatment with histamine or AII decreased subsequent caffeine responses by 100% and 90% respectively.”

“Depletion of the caffeine-sensitive Ca2+ store with ryanodine (3 x 10(-5) M) and repetitive applications of caffeine (2.5 x 10(-2) M) scarcely affected contractile and Ca2+i responses to histamine.”