Possible Interaction: Caffeine and Haloperidol

“Recently, it was shown that … with moderate doses of caffeine (5 mg/kg/day) during six months, followed by a withdrawal period of … weeks, developed a greater resistance to the catalepsy induced with the dopaminergic antagonist haloperidol , which was possibly mediated by an … dopaminergic transmission in the corpus striatum.”

“The dopamine antagonist haloperidol was only marginally effective in controlling SB produced by daily caffeine but the dopamine antagonist pimozide (which has a longer duration of action) prevented SB by amphetamine pellet rats.”

“ Haloperidol induced significantly higher Arc mRNA levels than both caffeine and caffeine plus haloperidol in the striatum.”

“These data indicate that both caffeine and nicotine trigger relevant molecular changes in PSD sites when given in association with haloperidol.”

“Treatment with caffeine significantly increased locomotion reduced by haloperidol , but not at all doses tested.”

“The adenosine A(2A) antagonist KW6002 (0.125-0.5 mg/kg IP) and the nonselective adenosine antagonist caffeine (5.0-20.0 mg/kg) significantly reversed the effects of haloperidol.”

“Besides, haloperidol also induced oxidative damage in all regions of brain which was prevented by caffeine and adenosine, especially in striatum.”

“On chronic administration of haloperidol there was a decrease in dopamine and norepinephrine turnover which was dose-dependently reversed by treatment with adenosine or caffeine.”

“As for apomorphine, the rotational behaviour elicited by caffeine (15.0 mg/kg SC) and theophylline (25.0 mg/kg SC) was inhibited by the dopamine antagonistscis-(Z)flupentixol, haloperidol and sulpiride.”

“The interaction profile of caffeine with haloperidol differed markedly from that of SCH 58261 in the forced swim and motor activity tests.”

“Pretreatment with low doses of caffeine (1-3 mg/kg), a non-selective adenosine antagonist, dose dependently reduced the intensity and increased the onset latency of catalepsy induced by haloperidol (0.5-2 mg/kg).”

“ HAL did not block the development of tolerance to the locomotor stimulant effects of caffeine , but did impair the recovery from tolerance following withdrawal of caffeine.”

“ HAL dose-dependently and completely blocked the acute effects of caffeine on locomotor activity, and the highest dose of GBR 12909 enhanced the effects of caffeine.”