Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Caffeine and Haloperidol

supplement:

Caffeine

Research Papers that Mention the Interaction

Recently, it was shown that … with moderate doses of caffeine (5 mg/kg/day) during six months, followed by a withdrawal period of … weeks, developed a greater resistance to the catalepsy induced with the dopaminergic antagonist haloperidol , which was possibly mediated by an … dopaminergic transmission in the corpus striatum.
Revista de neurologia  •  2010  |  View Paper
The dopamine antagonist haloperidol was only marginally effective in controlling SB produced by daily caffeine but the dopamine antagonist pimozide (which has a longer duration of action) prevented SB by amphetamine pellet rats.
Pharmacology Biochemistry and Behavior  •  1982  |  View Paper
Haloperidol induced significantly higher Arc mRNA levels than both caffeine and caffeine plus haloperidol in the striatum.
These data indicate that both caffeine and nicotine trigger relevant molecular changes in PSD sites when given in association with haloperidol.
European Neuropsychopharmacology  •  2018  |  View Paper
Treatment with caffeine significantly increased locomotion reduced by haloperidol , but not at all doses tested.
Pharmacology Biochemistry and Behavior  •  2009  |  View Paper
The adenosine A(2A) antagonist KW6002 (0.125-0.5 mg/kg IP) and the nonselective adenosine antagonist caffeine (5.0-20.0 mg/kg) significantly reversed the effects of haloperidol.
Behavioural Brain Research  •  2009  |  View Paper
Besides, haloperidol also induced oxidative damage in all regions of brain which was prevented by caffeine and adenosine, especially in striatum.
On chronic administration of haloperidol there was a decrease in dopamine and norepinephrine turnover which was dose-dependently reversed by treatment with adenosine or caffeine.
European journal of pharmacology  •  2006  |  View Paper
As for apomorphine, the rotational behaviour elicited by caffeine (15.0 mg/kg SC) and theophylline (25.0 mg/kg SC) was inhibited by the dopamine antagonistscis-(Z)flupentixol, haloperidol and sulpiride.
Psychopharmacology  •  2004  |  View Paper
The interaction profile of caffeine with haloperidol differed markedly from that of SCH 58261 in the forced swim and motor activity tests.
Neurology  •  2003  |  View Paper
Pretreatment with low doses of caffeine (1-3 mg/kg), a non-selective adenosine antagonist, dose dependently reduced the intensity and increased the onset latency of catalepsy induced by haloperidol (0.5-2 mg/kg).
Neuropharmacology  •  2003  |  View Paper
HAL did not block the development of tolerance to the locomotor stimulant effects of caffeine , but did impair the recovery from tolerance following withdrawal of caffeine.
HAL dose-dependently and completely blocked the acute effects of caffeine on locomotor activity, and the highest dose of GBR 12909 enhanced the effects of caffeine.
Pharmacology Biochemistry and Behavior  •  2001  |  View Paper
Show More