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Last Updated: 3 months ago

Possible Interaction: Caffeine and Halofantrine

supplement:

Caffeine

Research Papers that Mention the Interaction

Phase solubility studies support the formation of a 1:1 complex between caffeine and halofantrine which is characterised by a K(1:1) constant of 2.75x10(3) M(-1) (pH 5.9).
The aqueous solubility of the antimalarial agent halofantrine in phosphate buffers pH 5.9 and 7.0 (ionic strength 0.08) is increased by the addition of caffeine and nicotinamide.
The greatest increase in solubility was observed at pH 5.9 where the basal solubility of halofantrine rose from 0.91 to 435 microM when 125 mM caffeine was added.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences  •  2000  |  View Paper