Possible Interaction: Caffeine and Glucose

“Administration of caffeine in decaffeinated coffee increased postprandial glucose and insulin responses (both P = 0.02).”

“In conclusion, compared with glucose alone, 5 mg x kg(-1) x h(-1) of caffeine coingested with glucose increases exogenous CHO oxidation, possibly as a result of an enhanced intestinal absorption.”

“The underlying mechanism is likely to relate to the combined effects of caffeine and glucose on the brain.”

“BACKGROUND Caffeine ingestion decreases the insulin sensitivity index (ISI) for an oral-glucose-tolerance test (OGTT) and decreases insulin-induced glucose disposal in lean male subjects during a hyperinsulinemic clamp.”

“These data suggest that there is some degree of synergy between the cognition-modulating effects of glucose and caffeine which merits further investigation.”

“These data support our hypothesis that caffeine ingestion decreases glucose disposal and suggests that adenosine plays a role in regulating glucose disposal in resting humans.”

“This represents a significant (P < 0.05) decrease (24%) in glucose disposal after caffeine ingestion.”

“We hypothesized that glucose disposal would be lower after the administration of caffeine compared with placebo.”

“ Caffeine , a widely available constituent of coffee, tea, soft drinks, confectioneries, and over-the-counter remedies for colds and flu, simultaneously decreases cerebral blood flow and increases use of cerebral glucose [6].”

“… glucose … caffeine has been shown to facilitate cognitive performance and mood compared to placebo or glucose alone, the relative contribution of caffeine and glucose to the … is difficult to ascertain, due to the paucity of studies that have appropriately compared the effects of these ingredients combined and in isolation.”

“ Caffeine may also induce reduced hepatic glucose output.”

“When caffeine , a stimulant of glycolysis in human sperm, was present along with glucose , sperm penetration was enhanced, but only after 6 h of sperm preincubation.”