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Last Updated: a year ago

Possible Interaction: Caffeine and Gabapentin

supplement:

Caffeine

Research Papers that Mention the Interaction

In case of newer antiepileptics, both acute and chronic caffeine decreased the protective potential of gabapentin and topiramate but not that of lamotrigine and tiagabine.
Przeglad lekarski  •  2007  |  View Paper
Participants reported use of gabapentin in combination with buprenorphine, other opioids, cocaine, and caffeine to produce sought-after central nervous system effects (e.g., muscle relaxation, pain reduction, sleep induction, feeling drunk, and feeling “high”).
Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors  •  2018  |  View Paper
Acute and chronic caffeine (23.1 and 46.2mg/kg) enhanced the impairment of motor coordination in mice pretreated with GBP whilst an opposite effect was observed in TPM injected mice and pretreated with chronic caffeine at 46.2mg/kg.
Pharmacological reports : PR  •  2016  |  View Paper
Gabapentin produced dose‐related inhibition of mechanical hyperalgesia over a 3‐week period, and this effect was blocked by concomitant caffeine or DPCPX administration 1 week after injuries.
Journal of the peripheral nervous system : JPNS  •  2015  |  View Paper