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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Caffeine
drug:
Gaba Agents
Research Papers that Mention the Interaction
“ Caffeine inhibits adenosinergic receptors, which in turn can produce activation via interaction with GABAergic and dopaminergic neurotransmission.”
What keeps us awake: the neuropharmacology of stimulants and wakefulness-promoting medications.“ Caffeine altered the construction of GABAergic neuronal networks in V1, as reflected by a reduced number of somatostatin‐containing GABA neurons at postnatal days 6–7, with the remaining ones showing poorly developed dendritic arbors.”
Early-life exposure to caffeine affects the construction and activity of cortical networks in mice“These results suggest that (a) the GABAergic system has direct role in the regulation of LA, and (b) caffeine potentiates LA by antagonism of the adenosine receptor and activation of the dopaminergic system which, in turn, reduces GABAergic activity through the reduction of cholinergic system.”
“Biochemical studies showed that caffeine in the nontolerant condition reduced GABAergic activity in cerebral cortex, corpus striaturn, cerebellum, hypothalamus and pons-medulla; but tolerance to caffeine (10 or 20 mg/kg per day, po) pushed up the GABAergic activity to the control value in all these regions of brain.”
“Additionally, caffeine has been found to suppress the inhibitory ( GABAergic ) activity and modulate GABA receptors.”
Caffeine induces neurobehavioral effects through modulating neurotransmitters
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