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Last Updated: 2 years ago

Possible Interaction: Caffeine and Fluvoxamine

supplement:

Caffeine

Research Papers that Mention the Interaction

The results indicate that intake of caffeine during fluvoxamine treatment may lead to caffeine intoxication.
fluvoxamine, … caffeine decreased from 107 ml min-1 to 21 ml min-1 and the half-life increased from 5 to 31 h. The N3-demethylation …; the N1- and N7-demethylation clearances decreased from 21 to 9 ml min-1 and from 14 to 6 ml min-1, respectively.
Pharmacogenetics  •  1996  |  View Paper
The pharmacokinetics of each compound administered as a … significantly altered after the administration of ketoconazole and fluvoxamine , showing statistically significant (p < 0.01) 12.8-, 8.1- and 3.2-fold increases … area under the plasma concentration-time curve from time zero to infinity (AUC∞) for midazolam, caffeine and ….
Clinical Pharmacokinetics  •  2012  |  View Paper
Caffeine significantly decreased the plasma concentrations at 6 time points (P<0.05) and total area under the plasma concentration-time curve (156.5±51.7 vs. 118.9±38.2 ng/h/mL, P<0.01) of FLV.
The present study suggests that caffeine slightly induces the metabolism of FLV , probably mediated by CYP1A2.
Therapeutic drug monitoring  •  2006  |  View Paper
voxamine si gnificantly reduced apparent … of caf feine (1 05 vs. 9.1 mL min(-1), P < 0.01; mean difference: 95.7 mL min(-1), 95% CI: 54.9-135.6), … prolonged its elimination half-life (4.9 vs. 56 h, P < 0.01; mean difference: 51 h, 95% CI: 26-76).
British journal of clinical pharmacology  •  2005  |  View Paper
Interaction between caffeine and fluvoxamine has been described in vivo, leading to lowering of total clearance of caffeine by 80% during fluvoxamine intake.
The selective serotonin re-uptake inhibitor, fluvoxamine , is a very potent inhibitor of CYP1A2, and accordingly causes pharmacokinetic interactions with drugs metabolised by CYP1A2, such as caffeine , theophylline, imipramine, tacrine and clozapine.
The study shows that fluvoxamine , as expected, is a potent inhibitor of the metabolism of caffeine in vitro.
Pharmacology & toxicology  •  1998  |  View Paper
Fluvoxamine and fluconazole significantly increased the Cmax and AUC of caffeine , and the AUC of omeprazole and midazolam.
Biopharmaceutics & drug disposition  •  2014  |  View Paper
Propylene glycol inhibited the activity of CYP2E1 as indicated by 84% reduction in the clearance of 3 mg/kg dose of chlorzoxazone, whereas fluvoxamine inhibited the activity of CYP1A2 as indicated by 40% reduction in the clearance of a 10 mg/kg dose of caffeine.
Pharmacology & toxicology  •  1995  |  View Paper
Potent inhibitors of CYP 1A2 such as fluvoxamine can precipitate caffeine toxicity.
International journal of psychiatry in clinical practice  •  2001  |  View Paper