“Interaction between caffeine and fluvoxamine has been described in vivo, leading to lowering of total clearance of caffeine by 80% during fluvoxamine intake.”
“The selective serotonin re-uptake inhibitor, fluvoxamine , is a very potent inhibitor of CYP1A2, and accordingly causes pharmacokinetic interactions with drugs metabolised by CYP1A2, such as caffeine , theophylline, imipramine, tacrine and clozapine.”
“The study shows that fluvoxamine , as expected, is a potent inhibitor of the metabolism of caffeine in vitro.”