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Last Updated: 2 years ago

Possible Interaction: Caffeine and Estradiol



Research Papers that Mention the Interaction

Males exposed to DCF and CAF exhibited a reduction of 17β-Estradiol (E2) concentration compared to control (CTL).
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP  •  2020  |  View Paper
These results demonstrate that peripubertal exposure to high caffeine increases estradiol production in the ovary; this may disturb the coordinated regulation of the hypothalamo-pituitary-ovarian axis, thereby interfering with sexual maturation.
Reproductive toxicology  •  2017  |  View Paper
Estradiol (100 microM) also blocked the contractile response to serotonin (10 microM) but not to caffeine (10 mM).
American journal of physiology. Cell physiology  •  2006  |  View Paper
There is evidence that during postnatal life, estradiol has an inhibitory effect on body fat, because ovariectomy results in an increase in body weight in females; mice without the alpha form of estrogen receptors are heavier than mice with normal estrogen receptors ( Heine et al., 2000).
Birth defects research. Part A, Clinical and molecular teratology  •  2005  |  View Paper
Furthermore the mitogenic actions of adrenaline, which stimulates adenylate cyclase (the enzyme responsible for cyclic AMP biosynthesis), and caffeine , which inhibits phosphodiesterase (the enzyme which degrades cyclic AMP) were also insensitive to oestradiol inhibition.
Journal of cellular physiology  •  1974  |  View Paper