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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
Research Papers that Mention the Interaction
“Males exposed to DCF and CAF exhibited a reduction of 17β-Estradiol (E2) concentration compared to control (CTL).”
Endocrine disruptive action of diclofenac and caffeine on Astyanax altiparanae males (Teleostei: Characiformes: Characidae).“These results demonstrate that peripubertal exposure to high caffeine increases estradiol production in the ovary; this may disturb the coordinated regulation of the hypothalamo-pituitary-ovarian axis, thereby interfering with sexual maturation.”
“ Estradiol (100 microM) also blocked the contractile response to serotonin (10 microM) but not to caffeine (10 mM).”
“There is evidence that during postnatal life, estradiol has an inhibitory effect on body fat, because ovariectomy results in an increase in body weight in females; mice without the alpha form of estrogen receptors are heavier than mice with normal estrogen receptors ( Heine et al., 2000).”
“Furthermore the mitogenic actions of adrenaline, which stimulates adenylate cyclase (the enzyme responsible for cyclic AMP biosynthesis), and caffeine , which inhibits phosphodiesterase (the enzyme which degrades cyclic AMP) were also insensitive to oestradiol inhibition.”
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