Possible Interaction: Caffeine and Epigallocatechin

“Co-transportation of EGCG , ECG, or EC with caffeine , theanine, serine, or glycine increased their apparent permeability coefficient [ Papp(AP-BL)] value by 3.42-5.40- fold, 1.19-5.75-fold, and 1.55-8.01-fold, respectively.”

“The addition of either caffeine or any one of the three amino acids decreased the expression of both MRP2 and P-gp induced by EGCG , and the expression of P-gp induced by ECG or EC also decreased.”

“ Caffeine significantly lowered the amount of lymph flow, regardless of whether it was infused alone (14.2 +/- 3.9 mL) or with EGCG (18.6 +/- 2.0 mL), compared with EGCG (22.2 +/- 2.2 mL) alone and the control group (23.2 +/- 3.8 mL).”

“However, the lymphatic outputs of oleic acid (exogenous fatty acid marker) and other fatty acids of endogenous origin were not affected by EGCG but were markedly lowered by caffeine and EGCG plus caffeine.”

“The lymphatic output of esterified CH also was significantly lower in rats infused with EGCG (7.9 +/- 0.7 micromol), caffeine (7.6 +/- 0.2 micromol), and EGCG plus caffeine (7.5 +/- 0.6 micromol) than rats in the control group (11.6 +/- 1.7 micromol).”

“The lymphatic total 14C-CH was significantly lowered by EGCG (21.1 +/- 2.1% dose), caffeine (27.9 +/- 1.7% dose), and EGCG plus caffeine (19.3 +/- 0.9% dose), compared with the control (32.4 +/- 1.6% dose).”

“The results indicate that both EGCG and caffeine inhibit lipid absorption and that the inhibitory effects of the 2 tea constituents are not synergistic but mediated by distinctly different mechanisms.”

“Theanine and caffeine promoted cell growth while concentrations of EGCG greater than 10μg/ml inhibited cell growth.”