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Possible Interaction: Caffeine and Ephedrine

supplement:

Caffeine

Research Papers that Mention the Interaction

The ingestion of a combination of caffeine (C) and ephedrine (E) has been reported to prolong exercise time to exhaustion during cycle ergometry at 85% VO2max.
Aviation, space, and environmental medicine  •  1999  |  View Paper
BACKGROUND Ingesting a combination of caffeine and ephedrine (C+E) has been shown to raise metabolic heat production and body temperature.
Aviation, space, and environmental medicine  •  1999  |  View Paper
Animal and human studies have suggested a thermogenic synergism between ephedrine (E), a beta-agonist, and caffeine (C), an adenosine antagonist, which may be suitable for the treatment of obesity.
In this dose ratio, ephedrine and caffeine exerted a supra-additive synergism, whereas the thermogenic effects of the other two combinations were only additive.
Metabolism: clinical and experimental  •  1991  |  View Paper
These studies indicate that relatively mild doses of dietary methylxanthines in combination with ephedrine can raise daily energy expenditure of those predisposed to obesity, mainly by correcting their defective thermogenic response to food.
International journal of obesity  •  1986  |  View Paper
Caffeine enhanced the effect of ephedrine on platelet function, and phenylpropanolamine amplified the inhibitory effect of aspirin on platelet aggregation.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis  •  2010  |  View Paper
Caffeine and ephedrine increase sympathetic activity and induce weight loss, of which 25% is due to increased metabolic rate and 75% is due to a reciprocally decreased food intake.
Medical hypotheses  •  2009  |  View Paper
Concomitant ingestion of caffeine slowed the absorption rate of ephedrine , which is mainly related to the amount of the former in the absorption compartment.
Different models showed that the simultaneous administration of caffeine , or the amount of caffeine in the absorption compartment, was associated with a slower rate of absorption of ephedrine.
British journal of clinical pharmacology  •  2005  |  View Paper
Finally, evidence to date strongly suggests that caffeine and ephedrine combined are quite effective in decreasing the rating of perceived exertion and this seems to be independent of the type of activity being performed.
From the metabolic point of view, combined ingestion of caffeine and ephedrine has been observed to increase blood glucose and lactate concentrations during exercise, wheareas qualitatively similar effects on lipid fuels (free fatty acids and glycerol) are less pronounced.
Sports medicine  •  2004  |  View Paper
Use of ephedra or ephedrine and caffeine is associated with increased risk of psychiatric, autonomic, or gastrointestinal symptoms, and heart palpitations.
JAMA  •  2003  |  View Paper
Caffeine may act synergistically with other drugs including ephedrine and anti-inflammatory agents.
Sports medicine  •  2001  |  View Paper
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