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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
Research Papers that Mention the Interaction
“The ingestion of a combination of caffeine (C) and ephedrine (E) has been reported to prolong exercise time to exhaustion during cycle ergometry at 85% VO2max.”
Combined caffeine and ephedrine ingestion improves run times of Canadian Forces Warrior Test.“BACKGROUND Ingesting a combination of caffeine and ephedrine (C+E) has been shown to raise metabolic heat production and body temperature.”
“Animal and human studies have suggested a thermogenic synergism between ephedrine (E), a beta-agonist, and caffeine (C), an adenosine antagonist, which may be suitable for the treatment of obesity.”
“In this dose ratio, ephedrine and caffeine exerted a supra-additive synergism, whereas the thermogenic effects of the other two combinations were only additive.”
“These studies indicate that relatively mild doses of dietary methylxanthines in combination with ephedrine can raise daily energy expenditure of those predisposed to obesity, mainly by correcting their defective thermogenic response to food.”
“ Ephedrine produced a significant BPM dose response from 0.5 to 5.0 µM. Caffeine increased BPM only at a toxic level of 250 µM. Adding caffeine to PEA or higenamine but not ephedrine further increased BPM.”
“ICAf was stable and ECAf increased by 11 (4-18%; P=0.005) with administration of ephedrine while SskinO₂ did not change.”
“The thermogenic combination of ephedrine plus caffeine is minimally effective, and adverse effects are usually transient.”
“ Caffeine enhanced the effect of ephedrine on platelet function, and phenylpropanolamine amplified the inhibitory effect of aspirin on platelet aggregation.”
“ Caffeine and ephedrine increase sympathetic activity and induce weight loss, of which 25% is due to increased metabolic rate and 75% is due to a reciprocally decreased food intake.”
“Concomitant ingestion of caffeine slowed the absorption rate of ephedrine , which is mainly related to the amount of the former in the absorption compartment.”
“Different models showed that the simultaneous administration of caffeine , or the amount of caffeine in the absorption compartment, was associated with a slower rate of absorption of ephedrine.”
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