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Last Updated: 5 months ago

Possible Interaction: Caffeine and Enoxacin

supplement:

Caffeine

Research Papers that Mention the Interaction

Thus pefloxacin caused a 2-fold decrease in caffeine clearance, and enoxacin caused a 6-fold decrease in caffeine clearance.
Clinical pharmacology and therapeutics  •  1999  |  View Paper
SummaryA number of quinolone antibacterial agents, particularly enoxacin , pefloxacin, pipemidic acid and ciprofloxacin, are known to decrease the clearance of methylxanthines.
Clinical pharmacokinetics  •  1992  |  View Paper
The naphthyridine derivative enoxacin and the pyrido-pyrimidine derivative pipemidic acid had caused marked inhibition of caffeine and paraxanthine metabolism, whereas the genuine quinolone derivatives norfloxacin and ciprofloxacin had little effect, and the pyrido-benzoxacine derivative ofloxacin had no detectable effect.
European Journal of Clinical Pharmacology  •  1988  |  View Paper
Intraindividual comparisons showed that ciprofloxacin and enoxacin significantly inhibited the elimination of caffeine.
Thus, caffeine should be avoided in patients with liver disorders, cardiac arrhythmias, latent epilepsy or in intensive care while undergoing treatment with enoxacin or ciprofloxacin.
Drugs  •  1987  |  View Paper
Enoxacin and ciprofloxacin impair the hepatic metabolism of theophylline and caffeine , leading to significantly increased serum concentrations.
Pharmacotherapy  •  1993  |  View Paper
Enoxacin is the strongest inhibitor of theophylline and caffeine metabolism , followed by tosufloxacin, ciprofloxacin, and pefloxacin.
The American journal of medicine  •  1993  |  View Paper
The metabolism of theophylline and caffeine is inhibited by enoxacin and ciprofloxacin such that the dosage of theophylline may need to be reduced in order to avoid toxicity.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America  •  1992  |  View Paper
These involve a decrease in absorption when fluoroquinolones are given in combination with multivalent metal cations and an inhibition in the metabolism of methylxanthines by fluoroquinolones such as ciprofloxacin, enoxacin , and norfloxacin.
The American journal of medicine  •  1991  |  View Paper
Fluoroquinolones, especially enoxacin , and to a lesser extent ciprofloxacin and pefloxacin, inhibit the metabolic clearance of theophylline and caffeine.
The Journal of antimicrobial chemotherapy  •  1990  |  View Paper
Oxo-metabolites of enoxacin and, to a lesser extent, pefloxacin and ciprofloxacin interfere with the hepatic elimination of theophylline and caffeine and may result in toxicity due to these agents if dosage is not modified.
Clinical and investigative medicine. Medecine clinique et experimentale  •  1989  |  View Paper
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