Possible Interaction: Caffeine and Doxorubicin Hydrochloride

“The concomitant administration of Bancha methylxanthines and doxorubicin showed a dose-dependent reduction in the serum biochemical parameters, indicating a decrease in the cardiac and renal tissue damage caused by the antibiotic.”

“ DOX combined with o-rMETase and caffeine led to regression of SS-PDOX.”

“ Caffeine and theobromine inhibited the doxorubicin efflux from tumor cells, increased the doxorubicin concentration in a tumor, and enhanced the antitumor effect of doxorubicin.”

“ Caffeine distributes, high level in tumor, keeps the cyclic AMP level, and effects glucose transport or doxorubicin transport depend on energy and inhibits doxorubicin efflux.”

“For the mentioned above, we thought as concerns the increase of antitumor activity of doxorubicin by caffeine which is xanthine derivatives as follows.”

“Furthermore, the doxorubicin efflux was promoted by the supply of energy (addition of glucose), influx was decreased relatively, doxorubicin efflux needs the existence of glucose and the inhibition of energy related drug export pump by caffeine induced inhibition of doxorubicin efflux.”

“Moreover, we investigated the … the combination of doxorubicin … caffeine or theobromine on the change in cyclic adenosine 3',5'-monophosphate (cyclic AMP) in tissues in vivo, and the effect … cyclic AMP on doxorubicin efflux in vitro, and measured the distribution of caffeine and theobromine in normal and tumor tissues.”

“The present data, in conjunction with evidence in the literature that caffeine protects cells against the cytotoxic effects of doxorubicin , suggest that caffeine may play a more general role in protecting cells against planar aromatic molecules such as intercalating agents.”

“In conclusion, this study provides preliminary evidence that caffeine , not chlorogenic acid, modulates the cytotoxicity of doxorubicin , gemcitabine, and paclitaxel in SH-SY5Y cells via different mechanisms.”

“Surprisingly, in spite of the antitumor activity displayed by PTX, our results indicate that methylxantine , per se does not induce senescence; however it inhibits senescence induced by ADR and at the same time increases apoptosis.”

“Sarcospheres showed strong resistance to doxorubicin and cisplatin, and caffeine , a DNA repair inhibitor, enhanced the efficacy of those drugs, suggesting that the drug resistance in sarcosphere cells was partly related to the efficient DNA repair ability.”

“ CAF + ADR resulted in a more pronounced decrease in IMGD versus PL (42%) compared to CAF (26%) or ADR (24%) alone; however, the effect was not fully additive (P= 0.08).”

“We hypothesized that CAF + ADR would elicit a greater effect than either CAF or ADR alone (i.e. that CAF effects would not be solely attributed to ADR).”

“Notably, HMGA2 enhances doxorubicin-elicited cell cycle delay in sub-G1 and G2-M and augments cell cycle dysregulation on cotreatment of doxorubicin and caffeine.”

“Furthermore, caffeine also inhibited the accumulation of p53 by a variety of stress-inducing agents in vivo, such as 5-fluorouracil, doxorubicin , mitomycin C, camptothecin and roscovitine.”