Cannabis, tobacco, and caffeine use modify the blood pressure reactivity protection of ascorbic acid

, and tobacco use are associated with increased mesolimbic 

Caffeine; the Forgotten Potential for Parkinson's Disease.

On the level of dopamine release, the literature suggests that

 release and the number of dopamine receptors in the striatum via A2a receptor antagonism.

Effects of Adolescent Caffeine Consumption on Cocaine Sensitivity

 levels and augmented dopamine release in the NAc in response to cocaine (5 mg/kg, i.p.).

Adenosine A1 and A2A receptors are not upstream of caffeine’s dopamine D2 receptor‐dependent aversive effects and dopamine‐independent rewarding effects

We show that pharmacological antagonism of

 not only blocks conditioned place aversion to 

, but also reveals dopamine blockade‐induced conditioned place preferences.

Possible role of caffeine in autism spectrum disorders, a new testable hypothesis.

 is an antagonist of adenosine receptors (Ribeiro and Sebastiao 2010), potentiates 

 neurotransmission, and improves attention (Temple 2009).

Role of the central ascending neurotransmitter systems in the psychostimulant effects of caffeine.

By targeting A1-A2A receptor heteromers in striatal glutamatergic terminals and A1 receptors in striatal dopaminergic terminals (presynaptic brake),

 induces glutamate-dependent and glutamate-independent release of 

Caffeine and schizophrenia.

, which might be expected to worsen positive symptoms and improve negative symptoms of schizophrenia and worsen tardive dyskinesia.

The Role of Dopamine in the Behavioral Effects of Caffeine in Animals and Humans

 has been proposed to mediate some of the behavioral effects of 

Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects

 activates noradrenaline neurons and seems to affect the local release of 

[Self-rated Caffeine Sensitivity: Implications for Personalized Sleep Medicine?].

Pharmacogenetic studies in humans demonstrate that functional polymorphisms of the genes encoding adenosine A2A receptors and

 transporters contribute to individual differences in impaired sleep quality by 

Caffeine increases striatal dopamine D2/D3 receptor availability in the human brain

Like other wake-promoting drugs (stimulants and modafinil),

 (DA) signaling in the brain, which it does predominantly by antagonizing adenosine A2A receptors (A2AR).

Energy drinks and visual health.

EDs include high amounts of caffeine (32 mg/100 ml, although some 250 ml drinks contain 80 mg, while 500 ml … acts on the nervous system exactly like psychoactive substances, producing dependency particularly in students who use these drinks for exams because

Caffeine, exercise and the brain.

 concentration especially in those brain areas linked with 'attention'.

A new approach to Parkinson's disease combining caffeine, methylphenidate, and anticholinergic agents: case histories, pharmacological data, and a conceptual framework from traditional Chinese medicine.

A positron emission tomographic scan study has demonstrated that

 stimulates D2 dopamine receptors and potentiates the release of 

Effects of a combination of 3,4-methylenedioxymeth amphetamine and caffeine on real time stimulated dopamine release in the rat striatum: Studies using fast cyclic voltammetry

Previous reports have also indicated that MDMA-related enhancement of

Caffeine promotes wakefulness via dopamine signaling in Drosophila

 is required for the wake-promoting effect of 

 in the fly, and that caffeine likely acts presynaptically to increase dopamine signaling.

Chronic caffeine treatment enhances the resilience to social defeat stress in mice.

 exerts antidepressant-like effects in chronic stress situations by increasing 

Biogenic amines, caffeine and tonic immobility in Tribolium castaneum.

Neuroprotection by caffeine: time course and role of its metabolites in the MPTP model of Parkinson's disease

 post-treatment also significantly attenuated striatal 

 when it was given 10 min, 30 min, 1 h or 2 h but not 4 h, 8 h or 24 h after MPTP injection.

Caffeine and a selective adenosine A2A receptor antagonist induce sensitization and cross-sensitization behavior associated with increased striatal dopamine in mice

 (10 mg/kg) or SCH58261 (2 mg/kg) increased the concentrations of 

, DOPAC and HVA, concomitant with increased TH phosphorylation at Ser31 and consequently enhanced TH activity in the striatal tissues in both caffeine- and SCH58261-sensitized mice.

Subchronic-intermittent caffeine amplifies the motor effects of amphetamine in rats

, the most widely consumed psychostimulant drug, acutely stimulates motor behaviour and enhances 

 agonists actions whilst chronically it induces tolerance to either caffeine- or dopamine agonist-induced motor activating effects.

Further studies on the behavioural and biochemical interaction between caffeine and L-DOPA

 in the brain, and the levels of DOPA in both brain and plasma following administration of L-DOPA, all increased when 

Subchronic intermittent caffeine administration to unilaterally 6-hydroxydopamine-lesioned rats sensitizes turning behaviour in response to dopamine D1 but not D2 receptor agonists

The results show that repeated intermittent

 exposure enhances the motor stimulant effects elicited by 

 agonists by a preferential sensitization of dopamine D1 receptors.

Caffeine produces contralateral rotation in rats with unilateral dopamine denervation: comparisons with apomorphine-induced responses

As for apomorphine, the rotational behaviour elicited by

 (15.0 mg/kg SC) and theophylline (25.0 mg/kg SC) was inhibited by the 

 antagonistscis-(Z)flupentixol, haloperidol and sulpiride.

 denervated striatum produced, dose-dependently (1.0–50.0 μg/μl), contralateral rotation.

Increased synthesis of adrenomedullary catecholamines induced by caffeine and theophylline

; no statistically significant decreases in adrenaline + noradrenaline were observed.

Adenosine receptor blockade reverses hypophagia and enhances locomotor activity of dopamine-deficient mice

 agonist-induced striatal c-Fos expression.

Caffeine Induces Dopamine and Glutamate Release in the Shell of the Nucleus Accumbens

Using in vivo microdialysis in freely moving rats, we demonstrate that systemic administration of behaviorally relevant doses of

 can preferentially increase extracellular levels of 

Differential Effects of Caffeine on Dopamine and Acetylcholine Transmission in Brain Areas of Drug-naive and Caffeine-pretreated Rats

 (0.25, 0.5, 1.0, 2.5 and 5.0 mg/kg) dose-dependently increased 

 and acetylcholine dialysate concentrations in the medial prefrontal cortex, while it did not affect dialysate dopamine in the shell and core of the nucleus accumbens.

Involvement of DARPP-32 phosphorylation in the stimulant action of caffeine

Here we show that the stimulatory effect of

 on motor activity in mice was greatly reduced following genetic deletion of DARPP-32 (

 and cyclic AMP-regulated phosphoprotein of relative molecular mass 32,000).

Functional coupling of secretion and capacitative calcium entry in PC12 cells.

 from the cells only in the presence of extracellular Ca2+, which was mimicked by CPA.

Caffeine regulates neurotensin and cholecystokinin messenger RNA expression in the rat striatum

We therefore concluded that in the intact striatum normally innervated by dopaminergic fibers,

, probably acting through a presynaptic A2 receptor, induced a relative 

 depletion which in turn led to the induction of neurotensin and cholecystokinin expression in subsets of striatal neurons.

Effects of S-2-(3-Methylaminopropylamino)ethyl Phosphorothioic Acid (WR-3689), Alone or Combined with Caffeine, On Catecholamine Content of Mouse Hypothalamus

 increased to 142 ± 13 pg/mg (P < 0.05) 4 hr after injection of 40 mg/kg of 

Opioid receptor mediation of the hypothermic response to caffeine.

The results reveal that opiate receptors (but not adrenoceptors, 5-HT,

 or benzodiazepine receptors) may play a role in modulating the hypothermic action of 

Caffeine and regional brain monoamine utilization in mice.

 (DA) utilization in the OB, OT, PC, septum (SP), HT and thalamus (TH) but by various metabolic routes.

Preferential effects of caffeine on limbic and cortical dopamine systems

 significantly depressed the firing rates of 

 neurons in the ventral tegmental area (A10 group), but had no significant effect on the firing rates of dopamine neurons in the substantia nigra zona compacta (A9 group).

Effects of caffeine on monoaminergic systems in mouse brain.

First, concentrations of 10(-7) M to 10(-2) M of

 were tested for their potency in inhibiting the carriers involved in the neuronal uptake of 

Potentiation of dopaminergic transmission by phosphodiesterase inhibitors and cyclic nucleotides

 and theophylline also potentiated the inhibitory response to 

, applied to the postsynaptic neurons by perfusion or iontophoresis, but the effects were generally much smaller (maximum potentiation 30%).

Ingestion of caffeine links dopamine and 5-hydroxytryptamine release during half immersion in 42°C hot water in a humans

 and prolactin were significantly higher in the 

 ingestion group than in the control group at the Post time point (P<0.001).

Caffeinated Drinks and the Human Body

 by blocking adenosine receptors brings about changes in the levels of neurotransmitters like adrenaline, 

, serotonin, acetylcholine, glutamate and GABA.

Caffeine and Substance Use Disorders.

 antagonizes the unwanted effects of alcohol by blocking the A1 receptors that mediate alcohol's somnogenic and ataxic effects.4 Furthermore, … means of interactions between A2A and D2 receptors, caffeine-mediated blockade of A2A receptors can potentiate the effects of alcohol-induced 

Sex differences in estimation of time intervals and in reaction time are removed by moderate but not high doses of caffeine in coffee

, probably the most consumed drug in the world, leads to an augmentation of 

The effects of dopamine agonists on rotational behavior in non‐tolerant and caffeine‐tolerant rats

 in tolerance to the locomotor stimulant effects of 

supp.ai

Discover Supplement-Drug Interactions

Possible Interaction: Caffeine and Dopamine

Share:

Caffeine

Dopamine

Research Papers that Mention the Interaction