Possible Interaction: Caffeine and Dinoprostone

“The results indicate that caffeine could effectively reduce PGE2 synthesis in HBx(+) hepatocytes by specifically blocking the PPARγ-EGR1-mPGES-1 pathway, thereby providing a new evidence of molecular biology for the hypothesis that drinking coffee is beneficial to HBV-infected patients.”

“2) In vitro, caffeine at 0.01mM significantly enhanced the compression-induced expression of RANKL and COX-2, as well as prostaglandin E2 production in the PDLtm.”

“However, addition of exogenous prostaglandin E2 (PGE2) to the culture in the presence of caffeine had the opposite effect, in which the viability was decreased and anion superoxide production was increased.”

“Neither cAMP-inducing agent IBMX (0.01 mM and 0.… (0.001 mM) inhibited cell proliferation, but combined with PGE2 these agents strongly inhibited proliferation … with the combination of caffeine and PGE2, suggesting possibly that the increase of intracellular cAMP … important role in the inhibitory effects of cell proliferation.”

“ Caffeine caused a marked dose-dependent increase in the PGE2 excretion.”

“The outputs of PGE2 and PGF2 alpha were also increased by caffeine.”

“4 In Ca2+‐free solution, various substances (oxytocin, sodium orthovanadate and prostaglandin E2 ) evoked sustained contractions that were suppressed by caffeine (5–10 mm).”

“ PGE2 potentiated the CA release induced by stimulation of nicotinic or muscarinic cholinergic receptors and also by stimulation with excess K+ or caffeine.”

“ PGE2 and some synthetic prostaglandins (11-deoxy-derivatives), which stimulate steroid output in vitro, enhanced the effect of caffeine.”

“The addition of caffeine to the medium increased cyclic AMP-14C concentrations slightly in taenia coli and, on a percentage basis, the addition of PGE2 in the presence of 2.5 mM caffeine caused similar increases in cyclic AMP-14C levels in taenia coli and in myometrium.”