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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“The positive inotropic and the arrhythmogenic effects of caffeine could be diminished by pretreating the fibres with propranolol or Ca antagonists ( diltiazem and verapamil).”
Electromechanical effects of caffeine in isolated human atrial fibres.“Identical concentrations of diltiazem but not nifedipine correspondingly suppressed the arrhythmogenic effects of caffeine in whole hearts.”
Caffeine-induced arrhythmias in murine hearts parallel changes in cellular Ca(2+) homeostasis.“Thapsigargin had no effect on these kinetics, but diltiazem , which inhibits the Na+/Ca2+ exchanger, markedly reduced the rate of calcium decrease and abolished caffeine action.”
“Contractile responses to caffeine and electrical stimulation also were suppressed by diltiazem in control tissue.”
“ Diltiazem inhibited and antagonized the abnormal contractures induced by halothane, caffeine and potassium chloride in isolated skeletal muscle from pigs susceptible to malignant hyperpyrexia (MHS).”
“ Diltiazem , in concentrations above 3 × 10−7m suppressed the contraction evoked by excess [K]o, ATP or caffeine , but the inhibitory action of diltiazem on the K‐induced contraction was greatest.”
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