“ Caffeine alone did not modify the diastolic pressure, whereas caffeine and digitalis rapidly increase it.”
“The addition of 10 mM caffeine to the digitalis-containing solution reduced the ventricular rate to 171 +/- 12 beats/min (P less than 0.001 vs. digitalis alone, not significant vs. control, n = 8) and abolished the digitalis-induced multiple pacemakers.”