Possible Interaction: Caffeine and Dietary Fiber

“In fact, caffeine may induce contractures in muscle fibres either fully polarised, or completely depolarised (Lüttgau and Oetliker, 1968).”

“The results suggest that caffeine increases the transmembrane Ca influx and enhances the release of Ca from the intracellular stores in human atrial fibres.”

“ Caffeine (1-40 mmol/1) was also pressure injected into slow fibres.”

“At low concentration ( 8 mm) caffeine induces a prolonged, maximal contracture in single frog fibres irrespective of the value of the membrane potential, which ultimately causes irreversible damage to the fibres (Luttgau & Oetliker, 1968).”

“These findings thus differ from earlier reports that high caffeine concentrations enhanced the prominence of delayed transient components in cut fibres.”

“In the 2-day denervated muscle the … 0.384 ± 0.030 μmol (mg fibre protein)–1 and 19.8 ± 1.9 nmol min–1 (mg fibre protein)–1, respectively, to … nmol min–1 (mg fibre protein)–1; the calculated amount of Ca2+ released upon stimulation by caffeine decreased …)–1.”

“The increase in … promoted by caffeine was decreased by: (a) 72% in the absence of external Na+ (Nao+); (…) 73% in Na(+)‐loaded muscles ([Na+]i = 98 mM); (c) 70% when fibres were depolarized to ‐27 mV ([K+]o = 50 mM); … (d) 80% in the presence of 5 mM amiloride.”

“skinned muscle fibres , the caffeine threshold concentration decreased significantly (P < 0.05).”

“The sensitivity of the myofibrillar proteins to Ca2+ measured in the intact fibre was increased in the presence of caffeine , confirming earlier findings on skinned muscle fibres.”

“ Caffeine (15‐25 mM) caused a rapid and dramatic increase in tetanic force when applied to severely fatigued fibres : force output rose from 29.8 +/‐ 1.5 to 82.5 +/‐ 1.2% (n = 13) of Po.”