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Last Updated: a year ago

Possible Interaction: Caffeine and Diclofenac

supplement:

Caffeine

Research Papers that Mention the Interaction

6.0), differing in their polarity indexes (medium chain triglycerides (MG), decyl oleate (DO), and isopropyl myristate (IPM), respectively), affects the colloidal structure of the alkylpolyglucoside-based vehicles and in vitro permeation profiles of two model drugs: diclofenac sodium (DC) and caffeine ( CF ), both sparingly soluble in water.
International journal of pharmaceutics  •  2009  |  View Paper
In conclusion, caffeine produces antinociceptive synergism when administered in combination with diclofenac , and this synergism is partially mediated by opioid mechanisms at the central level.
The aim of this study was to analyze whether the administration of diclofenac combined with caffeine produced antinociceptive synergism and whether opioid mechanisms played a role in this event.
The maximal antinociceptive effect was obtained with the combination of 10.0 mg/kg diclofenac and 1.0 mg/kg of caffeine , with an effect of 76.7 ± 5.6%.
ISRN Pain  •  2013  |  View Paper