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Possible Interaction: Caffeine and Diazoxide

supplement:

Caffeine

Research Papers that Mention the Interaction

Although there was no difference in plasma diazoxide levels, maximal pulse or BP response to diazoxide between the two arms of the study, the renin response was significantly greater in the presence of caffeine.
The ability of the adenosine receptor blocker, caffeine , to augment renin release in response to the vasodilator, diazoxide , has been investigated in eight normal subjects in a double-blind, placebo-controlled, cross-over study.
These data confirm that caffeine augments the PRA response to diazoxide and suggest that endogenous adenosine inhibits stimulated renin response in humans.
The Journal of pharmacology and experimental therapeutics  •  1989  |  View Paper