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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Caffeine
drug:
Desipramine
Research Papers that Mention the Interaction
“ Desipramine decreased the rates of 1-N-, 3-N- and 7-N-demethylations, and 8-hydroxylation of caffeine (Ki = 23.3, 36.6, 23.3 and 63.3 microM, respectively), the effect on 1-N- and 7-N-demethylation being the most pronounced.”
Effects of classic and newer antidepressants on the oxidation pathways of caffeine in rat liver. In vitro study.“Intracerebroventricular 5,7-dihydroxytryptamine ( /- desipramine ) (which depleted central 5-HT systems) inhibited antinociception by caffeine but had no effect on locomotor stimulation.”
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