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Discover Supplement-Drug Interactions

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Last Updated: 5 months ago

Possible Interaction: Caffeine and Deamino Arginine Vasopressin

Research Papers that Mention the Interaction

Caffeine enhanced the effect of DDAVP to stimulate transepithelial short-circuit current of polarized ADPKD monolayers, reflecting an increase in chloride secretion.
Caffeine potentiated the effect of DDAVP and PGE(2) to increase the levels of phosphorylated extracellular signal-regulated kinase (P-ERK).
More importantly, clinically relevant concentrations of caffeine (10 to 50 micro M) potentiated the effects of desmopressin (DDAVP), prostaglandin E(2) (PGE(2)), and isoproterenol to increase cAMP levels in both ADPKD and HKC cells.
Journal of the American Society of Nephrology : JASN  •  2002  |  View Paper