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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Caffeine and Ddavp

supplement:

Caffeine

drug:

Ddavp

Research Papers that Mention the Interaction

Caffeine enhanced the effect of DDAVP to stimulate transepithelial short-circuit current of polarized ADPKD monolayers, reflecting an increase in chloride secretion.
Caffeine potentiated the effect of DDAVP and PGE(2) to increase the levels of phosphorylated extracellular signal-regulated kinase (P-ERK).
More importantly, clinically relevant concentrations of caffeine (10 to 50 micro M) potentiated the effects of desmopressin ( DDAVP ), prostaglandin E(2) (PGE(2)), and isoproterenol to increase cAMP levels in both ADPKD and HKC cells.
Journal of the American Society of Nephrology : JASN  •  2002  |  View Paper