Possible Interaction: Caffeine and Dantrolene

“In addition, the responses of Ala4894Thr-transfected cells and Ala4894Ser-transfected cells to caffeine were suppressed by dantrolene.”

“To a lesser extent dantrolene inhibits caffeine induced contractures of skeletal muscle fascicles, probably by indirectly accelerating the uptake of calcium into the SR.”

“The effect of caffeine was attenuated by exposure to the ryanodine receptor blocker dantrolene or when the membrane‐impermeant inositol trisphosphate receptor antagonist, heparin, was entrapped into synaptosomes; the combined treatment with dantrolene and heparin abolished the release elicited by caffeine.”

“Thus, the afterhyperpolarization is enhanced by caffeine , whereas it is inhibited by dantrolene and ruthenium red, two blockers of calcium-induced calcium release.”

“In contrast, the addition of caffeine abolished the protective effects of dantrolene on the tonic-clonic seizure/death and inhibited the beneficial effects of dantrolene on the severity of pentylenetetrazol seizures.”

“ Dantrolene and nifedipine completely inhibited increases in [Ca2+]i after treatment with caffeine and (±)‐BayK, respectively.”

“The negative effect of caffeine on AICAR-induced GLUT-4 expression was reduced by dantrolene , which desensitizes the ryanodine receptor.”

“The negative inotropic effect persisted in … of and after equilibration with caffeine (20 mmol/l) or ryanodine (2 μmol/l).5.… conclude that the direct negative inotropic effect of dantrolene cannot be attributed to overt effects on the sarcolemma such … an inhibition of fast Na or slow Ca channels.”

“Treatment with 100 microM dantrolene for 120 min reduced the increase in DA release induced by caffeine.”

“Enhanced sensitivity to caffeine was inhibited by dantrolene (20 μM) and its watersoluble analogue azumolene (150 μM).”