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Last Updated: 2 years ago

Possible Interaction: Caffeine and Dantrolene

supplement:

Caffeine

Research Papers that Mention the Interaction

In addition, the responses of Ala4894Thr-transfected cells and Ala4894Ser-transfected cells to caffeine were suppressed by dantrolene.
Anesthesia and analgesia  •  2011  |  View Paper
To a lesser extent dantrolene inhibits caffeine induced contractures of skeletal muscle fascicles, probably by indirectly accelerating the uptake of calcium into the SR.
Canadian Anaesthetists' Society journal  •  1984  |  View Paper
The effect of caffeine was attenuated by exposure to the ryanodine receptor blocker dantrolene or when the membrane‐impermeant inositol trisphosphate receptor antagonist, heparin, was entrapped into synaptosomes; the combined treatment with dantrolene and heparin abolished the release elicited by caffeine.
British journal of pharmacology  •  2000  |  View Paper
Thus, the afterhyperpolarization is enhanced by caffeine , whereas it is inhibited by dantrolene and ruthenium red, two blockers of calcium-induced calcium release.
Molecular pharmacology  •  1996  |  View Paper
In contrast, the addition of caffeine abolished the protective effects of dantrolene on the tonic-clonic seizure/death and inhibited the beneficial effects of dantrolene on the severity of pentylenetetrazol seizures.
Acta medica Iranica  •  2016  |  View Paper
Dantrolene and nifedipine completely inhibited increases in [Ca2+]i after treatment with caffeine and (±)‐BayK, respectively.
Development, growth & differentiation  •  2011  |  View Paper
The negative effect of caffeine on AICAR-induced GLUT-4 expression was reduced by dantrolene , which desensitizes the ryanodine receptor.
American journal of physiology. Cell physiology  •  2009  |  View Paper
The negative inotropic effect persisted in … of and after equilibration with caffeine (20 mmol/l) or ryanodine (2 μmol/l).5.… conclude that the direct negative inotropic effect of dantrolene cannot be attributed to overt effects on the sarcolemma such … an inhibition of fast Na or slow Ca channels.
Naunyn-Schmiedeberg's Archives of Pharmacology  •  2004  |  View Paper
Treatment with 100 microM dantrolene for 120 min reduced the increase in DA release induced by caffeine.
Neurochemistry International  •  1998  |  View Paper
Enhanced sensitivity to caffeine was inhibited by dantrolene (20 μM) and its watersoluble analogue azumolene (150 μM).
Journal of cellular physiology  •  1995  |  View Paper
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