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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Caffeine
drug:
Dactinomycin
Research Papers that Mention the Interaction
“1,3,7-Trimethylxanthine "caffeine" CAF ) is reported to induce a differential effect on the cytotoxicity of the DNA intercalators actinomycin-D versus Adriamycin (ADR).”
Modulation of adriamycin and N-trifluoroacetyladriamycin-14-valerate induced effects on cell cycle traverse and cytotoxicity in P388 mouse leukemia cells by caffeine and the calmodulin inhibitor trifluoperazine.“It is concluded that hetero-association of caffeine and actinomycin D molecules a lowers the effective concentration of the drug in solution and hence the pharmacological activity of actinomycin D.”
[1H-NMR analysis of heteroassociation of caffeine with antibiotic actinomycin D in the aqueous solution].“The presence of the nucleic acid inhibitor, either 2 mM hydroxyurea, … arabinofuranosyl cytosine, 2 mM excess dThd or 5 microg/ml of actinomycin D (AMD) during 2- to 24-h chase periods after a 2 … postirradiation label prevents the repair to various extents, while 2 mM caffeine completely … it.”
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