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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Caffeine
drug:
Cytarabine
Research Papers that Mention the Interaction
“…,caffeine , which is a well-known inhibitor of DNA damage … in DNA ligase I in MiaPaCa cells treated with ara-C and aphidicolin, suggesting that caffeine-sensitive kinases might be important mediators in the pathway … DNA ligase I levels in response to anticancer drugs, including ara-C and aphidicolin.”
Induction of DNA ligase I by 1-beta-D-arabinosylcytosine and aphidicolin in MiaPaCa human pancreatic cancer cells.“Likewise, a 3-fold increase was observed in the frequencies of chromosomal aberrations when caffeine and ara-C were combined.”
“ Caffeine and HU inhibited US of DNA more intensely in PGA-stimulated cells, and ara-C and ara-C in combination with HU--in unstimulated cells.”
“ Caffeine also enhanced SCEs induced by Ara-C in cultured human lymphocytes.”
“In a combined study, in vivo and in vitro, lymphocytes taken from 2 leukemic patients who had been given chlorambucil (CBC) or Ara-C by injection 3 h before, and then treated with caffeine in vitro, were found to have synergistically increased exchange frequencies.”
“The presence of the nucleic acid … 2 mM hydroxyurea, 50 microM arabinofuranosyl cytosine , 2 mM excess dThd or 5 microg/ml of actinomycin D (AMD) during 2- to 24-h … periods after a 2 h postirradiation label prevents the repair to various extents, while 2 mM caffeine completely … it.”
Postreplication repair of ultraviolet damage to DNA, DNA-chain elongation, and effects of metabolic inhibitors in mouse L cells.
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