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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Caffeine
drug:
Cyclosporine
Research Papers that Mention the Interaction
“… caffeine … cyclosporin A (CsA) and KN93, whereas cardiomyocyte hypertrophy induced by Ang II was inhibited by KN93, but not CsA. Our results show that cardiomyocyte hypertrophy … activity, contractile performance and signaling pathways of CaMKII and/or calcineurin, whereas the Ca2+ overload is not sufficient to cause the cardiomyocyte hypertrophy.”
Effect of distinct sources of Ca2+ on cardiac hypertrophy in cardiomyocytes“Thus we conclude, that … stimulating effect of cyclosporin on Ca2+ accumulation by the … mitochondria is sensitive to caffeine , while caffeine has no direct effect on Ca2+-uniporter, but it evidently disturbs the barrier function … the inner mitochondria membrane in such way, that stimulating effect of cyclosporin A cannot develop.”
“In addition, CsA accelerated the recovery and/or prevented the decrease of caffeine elimination 24 h after PHx but not at later time points, indicating an early, but unsustained, beneficial effect of CsA on the recovery of CYP1A2-mediated activities.”
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