Possible Interaction: Caffeine and Cyclophosphamide

“ CPM protein was decreased to 47.5% in patients with CAF compared with controls (P<0.01).”

“This synergistic effect of caffeine was also observed with cyclophosphamide (44.8%), mitomycin C (44.8%) and adriamycin (27.8%).”

“ Caffeine showed a marked synergistic effect on sarcoma cells with the DNA-damaging agents, ADR, CDDP, CPM and MMC in terms of colony inhibition.”

“In combination with other … same processing conditions caffeine at doses of 10 and … significantly increased cytogenetic effects of cyclophosphamide (20 mg/kg) in the pretreatment of the animals and at the dose of 100 … attenuated the cytogenetic effect of cisplatin (5 mg/kg) in single and repeated co-administration.”

“Aberrations induced by cyclophosphamide (40 mg/kg) were strongly potentiated by simultaneous application of caffeine (200 mg/kg) not only additively but even synergistically.”

“Results of the bone marrow micronucleus … genotoxic effects revealed that both caffeinated and decaffeinated instant coffee (140 mg/kg body weight/day) could …-genotoxic effects against ip injected benzo[a]pyrene (BP), cyclophosphamide ( CPH ), 7,12-dimethylbenz[a]anthracene (DMBA), mitomycin C (… procarbazine (PCB) in animals pretreated by gavage.”

“Treatment of SR with channel activators (micromolar Ca2+, nanomolar ryanodine, or millimolar caffeine ), 1) slows CPM labeling kinetics > 10-fold, 2) negates CPM labeling of channel-associated sulfhydryls, and 3) stabilizes a high molecular weight complex (HMWC) which appears on nonreducing SDS-polyacrylamide gel electrophoresis gels.”

“ Caffeine increased the survival time of the Ehrlich ascites tumor-bearing mice treated with CP and markedly reduced the ascitic volume.”

“Therefore, the in vivo antitumor effect by CP in conjunction with caffeine appears to correlate well with the in vivo synergistic effect on cytogenetic damage caused by the combined CP plus caffeine treatment.”

“However, when CF was given 6 h after CPA , a potentiated increase of embryolethality was observed at term and of structural chromosomal aberrations in embryos even before implantation, while sister chromatid exchange (SCE) frequency was less increased than after single CPA treatment.”