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Last Updated: 4 months ago

Possible Interaction: Caffeine and Cyclophosphamide

supplement:

Caffeine

Research Papers that Mention the Interaction

CPM protein was decreased to 47.5% in patients with CAF compared with controls (P<0.01).
Journal of molecular and cellular cardiology  •  2001  |  View Paper
This synergistic effect of caffeine was also observed with cyclophosphamide (44.8%), mitomycin C (44.8%) and adriamycin (27.8%).
Japanese journal of cancer research : Gann  •  1989  |  View Paper
Caffeine showed a marked synergistic effect on sarcoma cells with the DNA-damaging agents, ADR, CDDP, CPM and MMC in terms of colony inhibition.
Gan to kagaku ryoho. Cancer & chemotherapy  •  1987  |  View Paper
In combination with other … same processing conditions caffeine at doses of 10 and … significantly increased cytogenetic effects of cyclophosphamide (20 mg/kg) in the pretreatment of the animals and at the dose of 100 … attenuated the cytogenetic effect of cisplatin (5 mg/kg) in single and repeated co-administration.
Gigiena i sanitariia  •  2015  |  View Paper
Results of the bone marrow micronucleus … genotoxic effects revealed that both caffeinated and decaffeinated instant coffee (140 mg/kg body weight/day) could …-genotoxic effects against ip injected benzo[a]pyrene (BP), cyclophosphamide ( CPH ), 7,12-dimethylbenz[a]anthracene (DMBA), mitomycin C (… procarbazine (PCB) in animals pretreated by gavage.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association  •  1999  |  View Paper
Caffeine increased the survival time of the Ehrlich ascites tumor-bearing mice treated with CP and markedly reduced the ascitic volume.
Therefore, the in vivo antitumor effect by CP in conjunction with caffeine appears to correlate well with the in vivo synergistic effect on cytogenetic damage caused by the combined CP plus caffeine treatment.
Cancer research  •  1988  |  View Paper
However, when CF was given 6 h after CPA , a potentiated increase of embryolethality was observed at term and of structural chromosomal aberrations in embryos even before implantation, while sister chromatid exchange (SCE) frequency was less increased than after single CPA treatment.
Teratogenesis, carcinogenesis, and mutagenesis  •  1987  |  View Paper
Aberrations induced by cyclophosphamide (40 mg/kg) were strongly potentiated by simultaneous application of caffeine (200 mg/kg) not only additively but even synergistically.
Human Genetics  •  1976  |  View Paper