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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Caffeine
drug:
Creatinine
Research Papers that Mention the Interaction
“Although baseline serum creatinine did not … by caffeine exposure, patients receiving caffeine had … peak creatinine (median 1.0 mg/dl vs. 1.5 mg/dl; p = 0.008) and absolute creatinine change (… 0.42 mg/dl vs. 0.68 mg/dl; p = 0.003) than those who did not.”
Caffeine exposure and acute kidney injury in premature infants with necrotizing enterocolitis and spontaneous intestinal perforation“Total urine output of water, calcium, magnesium, sodium, chloride, potassium and creatinine increased in the two hours following caffeine ingestion when compared to the control beverage.”
“Urine flow rate (+63 +/- 57%), water output/input ratio (+49 +/- 54%) and creatinine clearance (+79 +/- 102%) increased significantly after the administration of caffeine.”
“Moreover, caffeine significantly decreased creatinine clearance after 4 and 8 weeks (CrCl, Cont:3.5 ± 0.4, Caff: 2.2 ± 0.2 L/kg/day, p<0.05) and increased protein/CrCl ratio (Cont:323 ± 30, Caff: 527 ± 33 mg/L/day).”
RENAL AND METABOLIC EFFECTS OF CAFFEINE IN OBESE (fa/facp), DIABETIC, HYPERTENSIVE ZSF1 RATS*“In addition, caffeine potentiated the transient reduction in creatinine clearance (CrCl) induced by PAN.”
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