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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Caffeine and Creatine

supplement:

Caffeine

supplement:

Creatine

Research Papers that Mention the Interaction

However, in a previous study, an exploratory analysis suggested that, in patients taking creatine, caffeine intake was associated with a faster rate of progression.
ResultsCaffeine intake was not associated with the rate of progression of PD in the main analysis, but higher caffeine intake was associated with significantly faster progression among subjects taking creatine.
These data indicate a potentially deleterious interaction between caffeine and creatine with respect to the rate of progression of PD.
Clinical neuropharmacology  •  2015  |  View Paper
Although scarce, research has suggested that caffeine ingestion may blunt the ergogenic effect of creatine.
International journal of sport nutrition and exercise metabolism  •  2015  |  View Paper
The myocardial content of adenosine triphosphate (ATP), creatine phosphate, as well as creatine was slightly but insignificantly increased after caffeine consumption.
Journal of cardiovascular pharmacology  •  2000  |  View Paper
The supplemented groups received creatine [load: 0.430 g/kg of body weight (BW) for 7 days; and maintenance: 0.143 g/kg of BW for 35 days], caffeine (15 mg/kg of BW for 42 days) or creatine plus caffeine.
Journal of the International Society of Sports Nutrition  •  2011  |  View Paper